Description
Composition:
1 ml of the preparation contains
active ingredients:
Amoxicillin – 150.0 mg;
Betamethasone – 0.5 mg.
Pharmacological properties:
Amoxicillin is a broad spectrum antibiotic of the aminopenicillin group.
It prevents the synthesis of the bacterial cell wall, inhibits the enzymes of transpeptidase and carboxypeptidase, causing osmotic pressure disorder in the bacterial cell, which leads to the death of bacteria during their growth stage.
The preparation is active against Gram-positive and Gram-negative microorganisms (Streptococcus spp., Pasteurella spp., Haemophilus spp.., Bacillus anthracis, Actinomyces spp., Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Actinobacillus spp., Bordetella bronchiseptica, Fusobacterium spp., Moraxella spp., Proteus mirabilis, Salmonella spp.).
The maximum concentration in plasma is reached in 1-2 hours after administration and is maintained at the therapeutic level for 48 hours.
Amoxicillin is practically not metabolized. It is excreted mainly with urine, to a lesser extent with milk and bile.
Betamethasone – belongs to the group of synthetic corticosteroids (adrenal cortex hormones), has anti-inflammatory, antipruritic, antiallergic, antiproliferative effect.
Betamethasone inhibits the functions of leukocytes and tissue macrophages. Restricts the migration of white blood cells in the inflammation area. Violates the ability of macrophages to phagocytosis, and the formation of interleukin-1.
Promotes the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the inflammation area.
Reduces capillary permeability due to the release of histamine.
Suppresses fibroblast activity and collagen formation.
Betamethasone dipropionate has a prolonged effect due to slow absorption.
The bioavailability of betamethasone is approximately 72%, the half-life is 5.6 hours, and 64% bind to plasma proteins.
It breaks down in the liver, is excreted by kidneys and only a small part is excreted with bile.
Target animals:
Cattle, pigs, dogs, cats.
Application:
Treatment of cattle and pigs: Diseases of the digestive tract (enteritis, gastroenteritis, gastroenterocolitis), respiratory organs (bronchitis, bronchopneumonia, rhinitis) and the genitourinary system (metritis, endometritis, mastitis, agalactia, cystitis, urethritis, pyelonephritis); joints, skin and soft tissues (umbilical cord infections, wounds, abscesses, inflammations), as well as treatment of animals for leptospirosis, actinomycosis, pig face, parainfluenza, parathypha caused by amoxicillin-sensitive microorganisms.
Treatment of dogs and cats: Diseases of the digestive tract (enteritis, gastroenteritis, gastroenterocolitis), respiratory organs (bronchitis, bronchopneumonia, rhinitis) and the genitourinary system (metritis, endometritis, mastitis, agalactia, cystitis, urethritis, pyelonephritis); joints, skin and soft tissue; acute and chronic otitis, surgical, wound, postnatal and other primary and secondary infections of bacterial etiology caused by amoxicillin-sensitive microorganisms.
Dose:
Intramuscularly or subcutaneously once in dose:
Cattle, pigs – 1 ml per 2.2lb(10 kg) of animal body weight;
Dogs, cats – 0.1 ml of the preparation per 2.2lb (1 kg) body weight of an animal.
If necessary, a second injection is given in 48 hours.
The period of withdrawal:
It is allowed to slaughter productive animals for meat in 21 days after the last application of the preparation.
The consumption of milk is allowed in 3 days after the last use of the preparation.
Meat and milk obtained before the specified period are disposed of or fed to non-productive animals, depending on the conclusion of the veterinary medicine doctor.
Shelf life – 2 years.
After the first selection of the drug from a bottle: 28 days if stored in a dry, dark place at temperatures between 40-77F (5 ° to 25 ° C).
The conditions of storage:
In a dark, inaccessible to children at temperatures between 40-77F.
(5° to 25°C).
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