Description
Homogeneous water-soluble powder from white to light yellow.
Composition:
1 gram of the product contains
active ingredients:
Lincomycin hydrochloride – 22 mg;
Spectinomycin sulfate – 22 mg.
Pharmacological properties:
ATC vet classification code QJ01 – antibacterial veterinary drugs for systemic use. QJ01FF52 – Lincomycin, combinations.
SP 44 – Combined preparation containing antibiotics – lyncomycin and spectinomycin.
The preparation has a wide range of antimicrobial action against Gram-positive and Gram-negative bacteria.
Lincomycin is an antibiotic from the group of lynchosamides.
It inhibits protein synthesis in microorganisms by binding to the 50S ribosomal subunit of bacterial cells. The substance has a bacteriostatic or bactericidal effect, depending on the concentration. Lincomycin mainly affects gram-positive microorganisms, including Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp., as well as gram-negative bacteria: Actinobacillus spp., Bordetella spp., Some species of Nocardias and Actinomyces spp., especially effective against Serpulina hyodysenteriae, Mycoplasma spp. and others.
Spectinomycin is an antibiotic of tricyclic structures of aminoglycosides group.
Its effectiveness is related to the suppression of protein synthesis in a microbial cell, binding to 30S ribosome subunit of microorganisms, prevents the elongation of polypeptide chain at the stage of translocation.
The substance acts mainly on gram-negative microorganisms including E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp., as well as on some gram-positive microorganisms and Mycoplasma spp.
Spectinomycin after oral administration is poorly absorbed in the digestive canal.
Spectinomycin binds to proteins by no more than 10%.
Its concentration in serum reaches a maximum after 2:00.
Small concentrations of antibiotic are observed in kidneys, liver, lungs, muscles, fatty tissue 24 hours after oral administration. Spectinomycin practically does not biotransform in the body and is excreted unchanged with feces.
After ingestion, lyncomycin is well absorbed from the digestive tract and well distributed in the organs and tissues, including bone tissue.
Lincomycin binds to proteins by 50%. The concentration of lyncomycin in serum is reached 2:00 after administration.
The half-life period is 2.5-4 hours.
Most lyncomycin and its metabolites are excreted mainly with urine and bile. Small amounts of the substance are excreted through the intestinal tract.
Application:
Treatment of poultry (broilers, breeding chickens, repair young animals) and pigs with enzootic pneumonia, colibacillosis, salmonellosis, dysentery, MMA syndrome (mastitis methyte agalactia), necrotic enteritis, mycoplasmosis, and gastrointestinal and respiratory diseases caused by lyncomycin and spectinomycin-sensitive microorganisms.
Dosage:
Oral with drinking water or food, individually or in groups, once a day in the following doses:
Pigs – 4.4lb (2 kg) of the preparation for 2200lb (1000kg) of feed for 5-7 days
Chickens (broilers, breeding chickens, repair young chickens) –
4.4lb (2 kg) of the preparation per 2200lb (1000kg) of feed (1-2 kg of the preparation per 1000 liters of drinking water), which corresponds to 2-3 grams of the preparation per 2.2lb (1 kg) body weight for 5-7 days.
When using the drug with feed it is recommended to first mix with 3-10% of the total feed, and then mix the resulting mixture with the rest of the feed.
When using the drug with drinking water solution is prepared on the basis of the required amount of drinking water for certain age categories of birds for 1 day. Daily prepare a fresh solution of the preparation.
Contraindications:
Do not use animals with hypersensitivity to lyncomycin and spectinomycin.
Do not use chicken laying eggs, which are intended for human consumption.
Do not use simultaneously with macrolides, chloramphenicol, ampicillin, kaolin, myorelaxants and anesthetics.
During treatment, do not prescribe medications that suppress intestinal peristalsis.
Do not use rabbits, hamsters, guinea pigs, horses, and especially ruminants; this can lead to severe complications of the gastrointestinal tract. Do not use in animals with impaired kidney and liver function.
Do not use pigs during pregnancy, lactation, and breeding.
Caution:
It is allowed to slaughter animals and poultry for meat in 3 days (pigs) and 2 days (broilers, repair young animals, breeding hens) after the last application of the drug. The meat is disposed of or fed to non-productive animals before the specified period, depending on the conclusion of the veterinary medicine doctor.
In some cases, after application of the preparation in pigs redness of skin and mucous membranes may occur, which does not require cancellation of the preparation.
In the process of mixing the preparation with feed it is necessary to use personal protective equipment (respirator, gloves).
Storage:
Dry, dark, inaccessible for children at temperatures between 40-77F (5 ° C to 25 ° C).
Shelf life – 2 years from the date of manufacture.
Shelf life of the drug, mixed with feed – 24-36 hours; when dissolved in water – 24 hours.
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