100ml ( Multivitamin Complex A,D3,E ) in animals with D-hypovitaminosis ( rachitis) and osteodystrophy, postpartum hypocalcaemia and hypophosphatemia, pre- and postpartum healing, alimentary and secondary dystrophy, delayed litter, subinvolution of uterus, endometritis, bone fractures

Description

 

Transparent oily liquid from light yellow to light brown odorless.

 

Composition

1 ml of the drug contains:

Vitamin A 30000 IU

vitamin D ₃                           40000 IU;

vitamin E 20 mg;

excipients: sunflower oil.

 

Pharmacological properties

Vitamin A  refers to fat-soluble vitamins, participates in redox processes, in carbohydrate and fat metabolism, and affects mineral and hormonal metabolism.

The mechanism of action of vitamin A is to regulate the absorption of oxygen in biochemical processes; inhibition of insulin activity and increased neoglycogenesis; activation of the metabolism of calcium and magnesium, which ensures the formation of the skeleton; slowing the formation of keratinogialin granules in the lipid layer of cell membranes and supporting the elasticity of cell membranes; ensuring the normal function of the organs of vision, skin, respiratory tract, digestive tract, reproductive system.

Vitamin A plays an important role in the interaction of proteins with lipids in cell membranes, ensures their functioning and regulates permeability. Membranes of lysosomes are most sensitive to vitamin A deficiency: with its deficiency, the elimination of enzymes from them increases. Structural abnormalities of mitochondrial membranes in hepatocytes lead to respiratory distress and phosphorylation. Vitamin A deficiency in animals enhances free radical oxidation; protein biosynthesis is disrupted in animal tissues, their electrophoretic properties change.

Vitamin A also ensures the normal functioning of the reproductive function of animals: sperm and oogenesis, development and growth of embryos, timely onset of puberty, synthesis of sex hormones.

Vitamin D ₃  belongs to the group of fat-soluble vitamins, affects the metabolism of calcium and phosphorus, starting with its absorption in the intestine and ending with its excretion from the body. Promotes the formation of animal bone tissue during the growth period, in the treatment of rickets, osteomalacia, bone fractures. Regulates the content of calcium and phosphorus in the blood and bone tissue, provides a physiological ratio of them in the body. With a decrease in the level of calcium in the blood, vitamin D ₃  provides its transition from bone tissue, affects tissue respiration and the oxidation of carbohydrates.

Vitamin E belongs to the group of fat-soluble vitamins and plays an important role as an oxidation regulator in protein biosynthesis; increases the content of myosin and actomyosin; provides ATP metabolism; prevents the oxidation of fats, fatty acids and sterols, delaying the oxidation of fats; prevents the formation of toxic metabolites; slows down the metabolism of carbohydrates, proteins, nucleic acids and steroids, and also ensures the stability of red blood cells to hemolysis and oxidation. Vitamin E provides the structure of cell membranes and intracellular inclusions, which leads to the stability of lysosomes and delays the release of lysosomal hydrolytic enzymes from them and prevents their participation in the development of dystrophy in white muscle disease. The effect of vitamin E on membrane structures positively affects the stability and functional activity of the integumentary epithelium of the mucous membranes of the digestive canal, uterus, and conjunctiva. Vitamin E ensures the normal functioning of the digestive and reproductive apparatus. In males, it regulates spermatogenesis and reduces the number of pathologically altered spermatozoa, prevents degeneration of the epithelium of the seminiferous tubules. In females, vitamin A promotes better attachment of the fetus to the uterus and fetal development.

 

Application

Treatment and prevention in animals of D-hypovitaminosis (rickets) and osteodystrophy, postpartum hypocalcemia and hypophosphatemia, pre- and postpartum bedding, alimentary and secondary dystrophy, litter retention, uterine subinvolution, endometritis, bone fractures. The drug is used for diseases that are accompanied by impaired absorption and metabolism of vitamins A and D (gastroenteritis, hepatitis, hepatodystrophy, hypothyroidism, glomerulonephritis).

 

Dosage

The drug for prophylactic purposes is administered intramuscularly or subcutaneously once every 7 days, with the drug intramuscularly once every 5 days until recovery (5-8 injections), in the future (if necessary) the drug is administered in preventive doses.

Doses of the drug are calculated according to vitamin D ₃ .

In order to fully provide animals with vitamin A, it is necessary to additionally administer drugs for prophylactic purposes once every 7 days, and for therapeutic purposes – once every 5 days in the following doses (thousand IU): for cows, respectively, 300-350 and 350-400; young cattle (per 100 kg of body weight) – 70-80 and 80-90; mares ribs – 200 and 400; nursing mares – 250 and 550; foals – 50 and 100; pregnant sows – 80 and 150; nursing sows – 120 and 150-200; piglets – 40 and 60-80; ewes to cats – 25 and 70; lactating ewes – 40 and 80; goats – 30 and 40.

Storage

A dry, dark place at a temperature of 5 ° C to 15 ° C.

Shelf life  – 2 years from the date of manufacture.

Shelf life (after the first opening of the bottle)  – 24 hours.