Description

 

 

Composition :

1 ml of the preparation contains

the active ingredient:

Ketoprofen – 100 mg.

 

 

Pharmacological properties:

Nesteroid anti-inflammatory agent with analgesic effect and antipyretic properties.

 

Pharmacodynamic action:

Ketoprofen belongs to the generation of non-steroidal anti-inflammatory agents based on propionic acid.

The inflammatory agent damages the cell and activates the phospholipidases that supply arachidonic acid. It is the basis for cyclogenase and lipoxygenase enzyme systems, which produce inflammatory substances such as prostaglandins, thromboxanes and leukotriens. Ketoprofen is a double inhibitor of inflammation, blocking the routes of action of cyclogenase and lipoxygenase, thus preventing the formation of prostaglandins and leukotriens.

In addition, ketoprofen is an analgesic agent that affects the central and peripheral nervous system. Its effect is to directly suppress bradykinin, vasodilator and pain mediator. In addition to the action against bradykinin, ketoprofen is active in the central nervous system, suppressing pain.

In horses ketoprofen neutralizes the effect of endotoxins and counteracts intestinal spasms that cause bradykinin.

 

 

Pharmacokinetic data:

Ketoprofen absorbs quickly. Cows have peak plasma levels (8.025±1.9 µg/ml) in less than an hour after administration, and the bioavailability of the substance ends. More than 98% binds to plasma proteins and accumulates in inflamed tissues. Ketoprofen has a high affinity with synovial tissues, it spreads and is excreted quickly. The duration of the drug is longer than expected, according to its half-life, which ranges from less than one hour (intravenous administration to horses) to more than five hours (after intramuscular administration to cattle).

Significant ketoprofen concentrations have been found in synovial fluid and are higher here than in plasma, and the half-life of ketoprofen is 2-3 times higher than in plasma. Ketoprofen is metabolized to insignificant biologically active metabolites, and 90% is excreted with urine in the form of glucuronide compounds.

 

 

Application:

Cattle: as anti-inflammatory, analgesic and antipyretic agent for the treatment of inflammatory processes caused by respiratory diseases, breast swelling, acute mastitis, inflammatory processes in the musculoskeletal system.

Horses: treatment of inflammatory and painful conditions in diseases of the musculoskeletal system (claudication of traumatic origin, arthritis, arthritis, arthrosis, joint injuries (ligament sprain, synovitis), fractures, tendinitis, hoof lesions (pododermatitis, claudication), inflammation after surgical interventions); symptomatic treatment of colic.

Pigs: anti-inflammatory, analgesic and antipyretic therapy for MMA syndrome, treatment of inflammatory and painful conditions in diseases of the musculoskeletal system, respiratory infections.

 

 

Dosage:

Cattle: intravenously or intramuscularly 3 ml of the preparation per 220lb (100kg) body weight  once a day for 1-3 days.

Horses: intravenously. For the treatment of bone and joint lesions, as well as musculoskeletal disorders, administer 1 ml of the preparation per 99lb (45kg) body weight , once a day for 3-5 days. For symptomatic treatment of colic, administer 1 ml of the preparation per 99lb (45kg) body weight once.

Additional injections are carried out only after a second clinical examination of the animal by a veterinarian.

Pigs: Intramuscularly 3 ml of the preparation per 220lb (100kg) body weightonce a day for 1-3 days.

 

Contraindications:
Use by animals with severe renal failure is contraindicated.

Do not administer to animals sensitive to ketoprofen.

 

 

Cautions:
After insertion, there may be local swelling, painful if touched, which can swell up to 10 cm within a radius and disappear a week after the end of treatment.

It is not allowed to inject foal mare or foal younger than 15 days of age.

Other non-steroidal anti-inflammatory agents, diuretics or anticoagulants should not be administered simultaneously.

Milk consumption for food is allowed to people without restrictions.

Killing animals for meat is allowed 4 days after the last injection of the drug.

 

 

Storage:

Dry dark place at temperature from  40-77F   (5 °С to 25 °С).

Shelf life – 2 years from the date of manufacture. Open bottle used within 7 days.