Description
CONTACTIONS
1 ml of the preparation contains
active ingredient
Danofloxacin – 25 mg;
PHARMACOLOGICAL PROPERTIES
Danofloxacin is a broad-spectrum chemotherapeutic agent belonging to the 4th generation of fluoroquinolones.
The mechanism of action of danofloxacin is based on deactivation of bacterial enzyme DNA-girase and topoisomerase IV, which leads to inhibition of bacterial DNA replication.
The preparation is active against Gram-positive and Gram-negative microorganisms (Staphylococcus aureus, Streptococcus pyogenes, Esherichia soli, Enterobacteriaceae spp.., Pasteurella spp., Haemophilus spp., Actinobacillus spp., Brucella spp., Bordetella bron chiseptica, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella spp. etc.), mycoplasm.
With parenteral administration, the maximum concentration of danofloxacin in blood is reached after 1 hour on average, the therapeutic concentration is maintained for 24 hours.
Danofloxacin has a high level of distribution in animals.
Thus, the concentrations in tissues and organs are much higher than in serum.
The organs with the highest concentration are the lungs, liver, kidneys, intestines and muscles.
Danofloxacin is partially metabolized in the liver and excreted from the body with urine and bile.
APPLICATION
Treatment of cattle and pigs with respiratory and digestive tract diseases caused by microorganisms sensitive to danofloxacin.
DOSE
| KIND OF ANIMAL | DOSAGE | MODE OF APPLICATION |
| Cattle | 0.5 ml of the drug per 22lb (10 kg) of body weight once a day for 3 days |
Subcutaneously |
| Pigs | Intramuscularly | |
| If necessary, the course of treatment can be extended for another 2 days. | ||
A maximum of 20 ml for cattle and 5 ml for pigs can be injected at one injection site.
HATCHING PERIOD
It is allowed to slaughter animals for meat in 5 (cattle) and 3 days (pigs) after the last application of the preparation. Humans are allowed to consume milk for food on the 4th day after the last application of the preparation. Meat and milk received before the specified period are disposed of (fed) to non-productive animals, depending on the conclusion of the veterinary medicine doctor.
Shelf life -2 years.
After the first opening of the bottle – 14 days under the condition of its storage in a dark place at temperatures from 40-77F (5 to 25 ° C).
STORAGE CONDITIONS
Store in a dark place out of reach of children at temperatures between 40-77F (5 to 25° C).
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