100ml ( Closantel 5% ) for Cattle, goats, sheep fasciolesis, nematodesis, hypodermosis, estrosis analogue of Solantel

Description

 

 

Composition

1 ml of the preparation contains

active ingredients:

Closantel – 50 mg.

 

 

 

Pharmacological properties:

The active ingredient of the preparation – Closantel – is an antiparasitic agent structurally derived

from salicylanylides, which has a long-term effect on endoparasites and ectoparasites.

Closantel blocks the process of phosphorylation (formation of ATP) in the body of parasites due to

interference in the processes of transportation of electrons, changing the energy metabolism, which

leads to the death of parasites.

Closantel has a wide range of effects and is effective in treating parasitic diseases of cattle and small

ruminants caused by nematodes, trematodes and arthropods.

Closantel is quickly absorbed by oral or intramuscular administration.

The maximum concentration in the blood of sheep is achieved 8-24 hours after the introduction,

and in the blood of cattle – 24-48 hours. The half-life is about 12-15 days.

More clozantel is concentrated in the lungs and kidneys, and the main way of its metabolism is the

restorative deionization.

 

 

Application:

Prevention and treatment of the following diseases in cattle and small ruminants

cattle:

– fasciole (Fasciola hepatica – mature and late larval forms);

– Nematodoses (adult and larval forms of Bunostomum spp., Haemonchus contortus, Haemonchus placei and Oesophagostomum radiatum);

– hypodermoses caused by subcutaneous larvae of Hypoderma spp..;

sheep, goats:

– fasciole (Fasciola hepatica sexually mature and late larval forms);

– nematodes (adult and larval forms of Bunostomum spp., Haemonchus contortus, Haemonchus placei and Oesophagostomum radiatum, Chabertia ovina);

– estrosis (Oestrosis ovis).

 

 

Dosage:

 

The drug is injected subcutaneously once in the following doses:

Cattle:

– at fasciolelosis – 0.5 ml of the preparation for 22 lb (10 kg) body weight (2.5 mg of closantel) per 2.2 lb (1 kg) body weight;

– nematoses – 0.5 ml per 22 lb (10 kg) of body weight (2.5 mg of closantel) per 2.2 lb (1 kg) of body weight;

– hypodermosis – 1 ml per 22lb (10 kg) of body weight (5 mg per 1 kg of body weight).

Sheep, goats:

– in fasciolesis – 1 ml per 22lb (10 kg) of body weight (5 mg of clozantel per 2.2lb (1 kg) of body weight);

– nematodes, estrose – 0.5 ml per 2.2lb (10 kg) of body weight (2.5 mg of clozantel per 1 kg of body weight).

It is recommended to divide the dose in half and introduce it in different places.

 

 

Contraindications:

Do not use simultaneously with antiparasitic organochlorine preparations. Do not use milk cows and pregnant suckers in the last trimester of pregnancy.

 

 

Cautions:

The slaughter of animals for meat is allowed after 28 days, the use of milk to feed people – 14 days after the application of the drug. At the place of administration of the preparation it is possible a slight inflammation which disappears independently in 2-3 days after administration.

Some breeds of cattle (charolais and its hybrids) are particularly sensitive to the drug. Approximately 2% of animals had anaphylactic reactions after the drug administration.

 

 

Storage:

Store in a dry, cool, light-proof place at a temperature of 40-77F (5 to 25 ° C).

Shelf life – 2 years from the date of manufacture.