1000 grams 2.2lb ( Sulfadimethoxin + Sulfadiazine + Trimetoprim ) Treatment of calves, lambs, horses, pigs, rabbits, dogs, cats, poultry (chickens, turkeys, ducks, geese) in gastrointestinal diseases (gastritis, enteritis, dyspepsia), respiratory diseases (angina, tracheitis, pharyngitis, bronchopneumonia, pleuritis), genitourinary system (postpartum sepsis, cystitis, urethritis, endometritis), postoperative complications, mastitis, actinomycosis, rye, dysentery, diplococcosis, enterotoxemia, eimeriosis, esherichiosis (collibacteriosis), pasteurellosis, pullorosis, oedema, mycoplasmosis, salmonellosis

Description

Composition :

contains 1 gram of the preparation:

Sulfadimethoxin sodium salt – 300 mg;

Sodium sulfadiazine – 300 mg;

Trimethoprim – 120 mg.

 

Description :

Powder of light yellow color, homogeneous, with weak specific odor, well soluble in water.

Pharmacological properties:
Combined broad spectrum antibacterial agent against Gram-positive and Gram-negative bacteria – Staphylococcus spp., Streptococcus spp., Neisseria spp., Clostridium spp.., Listeria monocytogenes, Corynebacterium spp., E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Citrobacter spp., Pasteurella spp., Bordetella spp, Enterobacter spp.., Yersinia enterocolitica, Chlamidya spp., Vibrio cholerae, etc., some simple Pneumocystis carinii, Coccidia, Toxoplasma.

Sulfonamides and trimethoprim (a derivative of diaminopyrimidine) block enzymes in two successive stages of folic acid biosynthesis in the cell of bacteria, which leads to the suppression of bacterial growth, cessation of their reproduction and death. The combination of active substances in the preparation reduces the probability of occurrence of resistant forms of pathogenic microflora.

Sulfonamides are rapidly distributed throughout the body, their therapeutic concentration is detected in serum within 25 hours. The concentration of sulfonamides in the kidneys is higher, and in the skin, liver and lungs is lower than in plasma.

Trimethoprim is rapidly distributed throughout the body, its maximum concentration is reached 4 hours after administration. The concentration of trimethoprim in the lungs, liver and kidneys is higher than in plasma.

Sulfonamides and trimethoprim are excreted by the kidneys through strawberry filtration and tubular secretion. Small amounts are metabolized in the liver and are excreted with bile.

 

Readings :
Treatment of calves, lambs up to 6 weeks of age, horses, pigs, rabbits, dogs, cats, poultry (chickens, turkeys, ducks, geese) in diseases of the gastrointestinal tract (gastritis, enteritis, dyspepsia), respiratory system (angina, tracheitis, pharyngitis, bronchopneumonia, pleuritis), genitourinary system (postpartum sepsis), cystitis, urethritis, endometritis), postoperative complications, as well as in mastitis, actinomycosis, rye, dysentery, diplococcosis, enterotoxemia, eimeriosis, Escherichia (collibacteriosis), washing, pasteurellosis, pullorosis, oedema, mycoplasmosis, salmonellosis.

 

Method of administration and dosage :

The drug is administered orally with drinking water or feed.

The dose is 0.3-0.35 grams per 22lb (10 kg) of body weight 1-2 times a day.

For poultry and rabbits, the dose is 1 grams of the drug per 3 liters of water, the course is 4-6 days. Depending on the clinical symptoms of the disease, the primary dose may be increased by 30-50%, and the course of treatment may be extended by 2-3 days.

At enterprises for the cultivation of pigs and poultry, the drug is given by a group method with water or feed in the doses shown in the table.

Animal species	Body weight, kg	Age, weeks	Daily dose of the drug, grams
			(( for 100 liter of water ))	(( per 220lb  (100 kg) of feed ))
Suckling pigs	to 22lb (10kg)		3   5-50	120-150
Weaned pigs	24-55lb (11-25kg)		25-35	65-80
Fattening pigs	57-220lb (26-100kg)		35-45	80-110
Sows	more than 330lb (150kg )		–	150-180
Chickens, turkeys, ducks, geese (young)		up to 1	13-15	–
		2-8	17	34
		9-18	25	50
Broiler chickens		1-4	15-18	30-33
		5-8	25	42

In the group method, the dose of the preparation is dissolved in half of the daily norm of water. Water without the preparation is given after the treatment solution is sold out.

Cautions :
Goats have a high sensitivity to sulfonamides, so they need to be injected very carefully.

After the last application of the drug slaughter of calves, lambs, pigs, rabbits for meat is allowed in 4 days, poultry – in 2 days. Meat obtained earlier than this period is disposed or fed to unproductive animals, depending on the conclusion of the veterinarian.

 

Contraindications :

Do not prescribe to animals with hypersensitivity to the active substances of the preparation, liver and kidney function disorders, ruminants with functionally formed pancreas. Do not use for the treatment of laying hens, whose eggs are eaten by people.

 

Conditions of storage :

In a dry, dark, inaccessible for children place at a temperature from 46-77F (+8 to +25 ° C).

 

Use the ready solution within a day, when stored in a refrigerator – within 3 days.

 

Shelf life – 2 years.