Description
DESCRIPTION
The suspension is white to almost yellowish-white in color. The suspension stratifies during storage.
COMPOSITION
1 ml of the product contains
active substances:
Procaine benzylpenicillin – 100 mg;
Benzathine benzylpenicillin – 100 mg;
Dihydrostreptomycin sulfate – 200 mg.
PHARMACOLOGICAL PROPERTIES
ATC vet classification code QJ01- antibacterial veterinary drugs for systemic use. QJ01RA01- Penicillins, combinations with other antimicrobials.
The active substances of the drug are procaine benzylpenicillin and benzathine benzylpenicillin, which belong to the beta-lactam antibiotics, penicillin group, and dihydrostreptomycin sulfate, which belongs to the antibacterial bactericidal agents of the aminoglycoside group.
Procaine benzylpenicillin shows bactericidal effect mainly on Gram-positive bacteria. The action of the substance is based on inhibition of the activity of enzymes of peptidoglycan synthesis, which leads to cessation of bacterial growth, and also activates enzymes that hydrolyze peptidoglycan, which weakens the covalent bonds of the cell wall. Bacterial cells stop dividing, enlarge, swell and disintegrate with the formation of small particles. The peculiarities of benzylpenicillin procaine are slow absorption and prolonged action when administered.
Benzathine benzylpenicillin is a beta-lactam antibiotic of the type G prolonged-acting penicillin group. It acts bactericidally on sensitive microorganisms by inhibiting synthesis of cell wall mucopeptides. It is active against Gram-positive microorganisms: Staphylococcus spp. (penicillinase-unforming, Streptococcus spp, including Streptococcus pneumoniae and Streptococcus pyogenes A, Corynebacterium diphtheriae, Erysipelothrix rhusiopathiae, anaerobic spore-forming bacilli: Bacillus anthracis, Clostridium spp., Actinomyces israelli; gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Treponema spp.
Penicillins are highly active against Gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., Corynebacterium diphtheriae and others). The mechanism of action is based on disruption of synthesis of mucopeptide peptidoglycan, which leads to inhibition of synthesis of the cell wall of the microorganism, suppression of growth and reproduction of bacteria.
Dihydrostreptomycin is an aminoglycoside antibiotic that acts bactericidally on Gram-negative and Gram-positive microorganisms (Pasteurella spp., Salmonella spp., E.coli, Klebsiella spp., Hemophilus spp., Brucella spp., Shigella spp., Mycobacterium spp.). The antibacterial effect is based on the binding of the streptomycin molecule to the ribosomal 30 S subunit of the microbial cell, which leads to the formation of inferior proteins, stopping the growth and development of the bacteria. Unlike benzylpenicillin procaine, dihydrostreptomycin sulfate acts on microorganisms in both the reproduction and quiescent stages.
After intramuscular administration, penicillins and dihydrostreptomycin are widely distributed throughout all body tissues. High concentrations are detected in the kidneys, liver, muscles and lungs.
When parenteral administration, penicillin is absorbed slowly, so its peak serum concentration is observed after 3-4 hours.
Dihydrostreptomycin is well absorbed from the injection site. It penetrates well into milk.
The peak concentration of dihydrostreptomycin is seen after 30-90 minutes, and it persists in the body at therapeutic concentration for at least 24 hours. Penicillin and dihydrostreptomycin are eliminated from the body mainly with the urine.
INDICATIONS FOR USE
Treatment of cattle, pigs, dogs and cats for diseases of the digestive tract (gastroenteritis, dyspepsia and diarrhea of various types), respiratory system (bronchitis, pneumonia of various etiologies) and urogenital system (metritis, mastitis, cystitis), as well as for purulent and secondary infections caused by microorganisms sensitive to the active substances of the drug, including Gram-positive bacteria: Clostridium spp, Corynebacterium spp., Erysipelothrix spp., Enterococcus spp., Listeria spp., Staphylococcus spp. (including Staphylococcus aureus), Streptococcus spp.; and Gram-negative microorganisms: Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp., Pasteurella spp., Brucella spp., Haemophilus spp., Campylobacter spp. etc., sensitive to penicillin and dihydrostreptomycin.
DIRECTIONS FOR USE AND DOSAGES
Shake the drug vial thoroughly before use.
Intramuscularly (pigs) or subcutaneously (cattle, dogs, cats) in dose 1 ml per 22lb (10 kg) of animal body weight once.
In severe cases repeated administration of the drug after 3 days is recommended.
CONTRAINDICATIONS
Do not use in animals with hypersensitivity to penicillins and dihydrostreptomycin.
Do not use in rabbits, guinea pigs, hamsters or other small herbivorous animals.
Do not use in animals with impaired kidney function.
Do not use simultaneously with other beta-lactam antibiotics from penicillin group G.
Do not use simultaneously with other antibiotics that have antagonism (gentamicin or kanamycin).
Do not use intravenously.
CAUTIONS
Slaughter of animals for meat is allowed 35 days (pigs) and 49 days (cattle) after the last drug administration. Consumption of milk is allowed 5 days after the last drug administration. Meat and milk obtained prior to the specified period shall be utilized or fed to non-productive animals depending on the opinion of a veterinarian.
STORAGE
STORAGE Dry, dark place at the temperature from 39-46F (4°C to 8°C), kept out of reach of children and animals, separated from foodstuff.
SHELF LIFE
Shelf life of the drug is 18 months (if stored in a dark, dry place at temperatures from 39-46F (4 ° C to 8 ° C).
Shelf life of the drug is 12 months (if stored in a dark, dry place at the temperature from 59-77F (15 ° C to 25 ° C).
After the first withdrawal from the bottle, the drug should be used within 28 days if stored in refrigerator at 39-46F (4 °C to 8 °C).
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